Vitamin D supplementation and cardiovascular disease risks in more than 83,000 individuals in 21 randomized clinical trial : A meta-analysis

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Vitamin D supplementation and cardiovascular disease risks in more than 83,000 individuals in 21 randomized clinical trial : A meta-analysis

JAMA — Barbarawi M, et al. | June 21, 2019

Via conducting a meta-analysis of 21 randomized clinical trials that included more than 83,000 participants, researchers tested the correlation of vitamin D supplementation with reduced cardiovascular disease (CVD) events and all-cause mortality. Compared with placebo, vitamin D supplementation was not linked to reduced major adverse cardiovascular events, individual CVD endpoints (myocardial infarction, stroke, CVD mortality), or all-cause mortality. Further, results were consistent by sex, baseline 25-hydroxyvitamin D level, vitamin D dosage, formulation (daily vs bolus dosing), and the presence or absence of concurrent calcium administration. Overall, vitamin D supplementation did not confer cardiovascular protection and, therefore, is not indicated for this purpose.