Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

I don't care about your use of big words and discussion/overview. Survivors want protocols for recovery.  GET THERE!  How the hell do we get stroke researchers to focus on the only reason for stroke research? 100% recovery for all. What stroke leaders do we need to convince that is the only goal?

Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

• Authors
• Authors and affiliations

• Yörg Dillen
• Hannelore Kemps
• Pascal Gervois
• Esther Wolfs
• Annelies Bronckaers

• Yörg Dillen
  • 1
• Hannelore Kemps
  • 1
• Pascal Gervois
  • 1
• Esther Wolfs
  • 1
• Annelies Bronckaers
  • 1
  Email authorView author's OrcID profile

1. 1.UHasselt, Hasselt UniversityBiomedical Research Institute (BIOMED) – Research Group of MorphologyDiepenbeekBelgium

Review

First Online: 15 July 2019

• 11 Downloads

Abstract

Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast implications for the fundamental understanding of the neurobiology of the brain and its potential to being harnessed for therapy in various neurological disorders. Investigation of adult neurogenesis has been complicated by the difficulties with characterization of neural stem cells in vivo. However, recent single-cell transcriptomic studies provide more detailed information on marker expression in neural stem cells and their neuronal lineage, which hopefully will result in a more unified discussion. Regulation of the multiple biological steps in adult neurogenesis comprises intrinsic mechanisms as well as extrinsic factors which together orchestrate the process. In this review, we describe the regulating factors and their cellular sources in the physiological condition and provide an overview of the regulating factors mediating stroke-induced stimulation of neurogenesis in the subventricular zone. While there is ongoing debate about the longevity of active post-natal neurogenesis in humans, the subventricular zone has the capacity to upregulate neurogenesis in response to ischemic stroke. Though, the stroke-induced neurogenesis in humans does not seem to translate into adequate functional recovery, which opens discussion about potential treatment strategies to harness this neuroregenerative response. Various therapeutic approaches are explored in preclinical and clinical studies to target endogenous neurogenesis of which some are discussed in this review.

Keywords

Adult neurogenesis Subventricular zone Ischemic stroke Neural stem cells Stroke therapy 

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Notes

Funding

This study was funded by grants of “Fonds voor Wetenschappelijk Onderzoek” (FWO) Vlaanderen and Research Funds of Hasselt University. Yörg Dillen is a predoctoral researcher of the “Fonds Wetenschappelijk Onderzoek” (FWO) Vlaanderen. Pascal Gervois, Esther Wolfs, Yörg Dillen and Annelies Bronckaers are funded by FWO grants 12U7718N, G0A7514N, 1134717N, FWO1522518. Hannelore Kemps is funded by the Special Research Fund (BOF) of Hasselt University” (Grant number 18NI06BOF).