Over
the past few years, the contribution of oxysterols to the onset and
development of some of the major neurodegenerative diseases (such as
Alzheimer’s and Parkinson’s diseases) has been scientifically asserted,
being mainly related to altered brain cholesterol homeostasis. To
counteract oxysterol induced inflammation at neuronal level, one
possible intervention approach is the administration of some nutrients
and/or plant secondary metabolites. On the other hand, the pleiotropic
beneficial effects of physical activity seem to play an important role
on prevention and counteraction of neurodegenerative diseases, through
the modulation of oxysterol homeostasis and the prevention of
demyelination. The present review provides a picture of the promising
role of nutraceuticals and physical activity on oxysterol-mediated
neurodegeneration, pointing out also the different in vitro and in vivo
aspects that need to be further investigated for a better understanding
of the association of these three counterparts and their overall effect
on people at increased risk for neurodegenerative diseases.
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