Tuesday, August 27, 2019

Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease

One would think that IMMEDIATELY upon reading this your doctor would create a food restriction protocol(intermittent fasting?).  You can't do this dangerous activity without your doctor's knowledge. 

These earlier ones already tell you how incompetent your doctor is. Why are you seeing him/her? Do you prefer your incompetence in NOT KNOWING, or NOT DOING?

Hungry stomach hormone promotes growth of new brain cells April 2017 

Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory February 2013

The latest here: 

Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease

Highlights

There is a close relationship between cognitive performance and nutritional status, but the mechanisms underlying this relationship are not well understood.
The hormone, ghrelin, which is released during food restriction, triggers adaptive responses to improve learning and memory by increasing the formation of new neurones in the adult brain.
The birth of new neurones (neurogenesis) from neural stem cells in the adult mammalian brain is an important process involved in protecting against the age-related decline in cognitive function.
Activation of the hippocampal ghrelin receptor may be a viable therapeutic approach to stimulate neurogenesis and protect against age- and disease-related cognitive decline.
There is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin, which is released during food restriction, provides a link between circulating energy state and adaptive brain function. The maintenance of such homeostatic systems is essential for an organism to thrive and survive, and accumulating evidence points to ghrelin being key in promoting adult hippocampal neurogenesis and memory. Aberrant neurogenesis is linked to cognitive decline in ageing and neurodegeneration. Therefore, identifying endogenous metabolic factors that regulate new adult-born neurone formation is an important objective in understanding the link between nutritional status and central nervous system (CNS) function. Here, we review current developments in our understanding of ghrelin’s role in regulating neurogenesis and memory function.

Keywords

ghrelin
calorie restriction
hippocampus
neurogenesis
neurodegeneration
learning and memory
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These authors contributed equally to this work.
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