Tuesday, September 10, 2019

Models to Tailor Brain Stimulation Therapies in Stroke

Every one of the 10 million yearly stroke survivors  knows perfectly well that nobody knows anything exact about recovering from a stroke. Our fucking failures of stroke associations are doing nothing to solve that, rather they would put out press releases and prevention crapola. 

Models to Tailor Brain Stimulation Therapies in Stroke

Neural Plasticity, 2016
A great challenge facing stroke rehabilitation is the lack of information on how to derive targeted therapies. As such, techniques once considered promising, such as brain stimulation, have demonstrated mixed efficacy across heterogeneous samples in clinical studies. Here, we explain reasons, citing its one-type-suits-all approach(Because you never created a damage diagnosis to be able to map effective stroke rehab protocols to damage. Stroke leaders are that fucking stupid) as the primary cause of variable efficacy. We present evidence supporting the role of alternate substrates, which can be targeted instead in patients with greater damage and deficit. Building on this groundwork, this review will also discuss different frameworks on how to tailor brain stimulation therapies. To the best of our knowledge, our report is the first instance that enumerates and compares across theoretical models from upper limb recovery and conditions like aphasia and depression. Here, we explain how different models capture heterogeneity across patients and how they can be used to predict which patients would best respond to what treatments to develop targeted, individualized brain stimulation therapies. Our intent is to weigh pros and cons of testing each type of model so brain stimulation is successfully tailored to maximize upper limb recovery in stroke.(What fucking laziness. We need protocols NOT pros and cons)
Doi: 10.1155/2016/4071620. Epub 2016 Feb 23.

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