Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure

Hydrogen sulfide research back to 2013 proved helpful for survivors and you do want BDNF. 8 posts on it here.  But shit once again nothing seems to have been done that might actually help stroke survivors. I blame our fucking failures of stroke associations, great at doing nothing for survivors. WHAT IS YOUR DOCTOR'S PROTOCOL FOR PROMOTING BDNF?

Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure

Author links open overlay panelFahimehMohseni^aFarzanehBagheri^bRahelehRafaiee^cPirastehNorozi^dMehdiKhaksari^e

https://doi.org/10.1016/j.physbeh.2019.112784Get rights and content

Highlights

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Hydrogen sulfide improve spatial memory impairment in a model of fetal alcohol spectrum disorders.

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Hydrogen sulfide reduced apoptotic cell death in model of fetal alcohol spectrum disorders

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Hydrogen sulfide increased neurogenesis in model of fetal alcohol spectrum disorders

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Hydrogen sulfide increased of BDNF expression in model of fetal alcohol spectrum disorders

Abstract

According to experimental and clinical findings, fetal brain development may be interrupted by maternal alcohol consumption during pregnancy. Adult hippocampal neurogenesis is thought to play a role in cognition function (i.e. learning and memory). Recent evidence suggests that ethanol administration causes major apoptotic neurodegeneration in many regions of the rats’ developing brain during the synaptogenesis period. Based on the recent studies, H₂S improve learning and memory via increased neurogenesis and antiapoptotic mechanisms in different animal models. In this study, we aimed to evaluate the protective effects of hydrogen sulfide on alcohol-induced memory impairment, hippocampus neurogenesis and neuronal apoptosis in rat pups with postnatal ethanol exposure.

Administration of ethanol to male rat pups was performed through intragastric intubation on postnatal days 2-10. The pups were administered 1 mg/kg of NaHS (H₂S donor) on postnatal days 2-10. For examining the spatial memory, Morris water maze test was carried out 36 days after birth. Following the behavioral test, immunohistochemical staining was performed to evaluate the expression levels of BrdU, BDNF and Apoptotic cell death was detected by TUNEL staining.

Hydrogen sulfide (H₂S) treatment could significantly improve spatial memory impairment (P< 0.05) and significantly increase the expression of BrdU and BDNF in dentate gyrus area (P< 0.05). It also decreased positive TUNEL cells, compared with the ethanol group (P< 0.01).

Based on the findings, H₂S makes significant neuroprotective effects on Ethanol neurotoxicity due to its neurogenesis and anti-apoptotic activity.