Estimated stroke-free survival of folic acid therapy for hypertensive adults

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Estimated stroke-free survival of folic acid therapy for hypertensive adults

Hypertension — Zhang T, Lin T, Wang Y, et al. | January 17, 2020

Researchers estimated the lifetime incremental stroke-free survival for enalapril-folic acid vs enalapril alone. They analyzed data from 19,053 participants and established adjusted models for competing risks and an age-based time scale. Findings revealed that a modest gain in lifetime stroke-free survival was achieved with enalapril plus folic acid treatment vs enalapril alone in hypertensive patients. In addition, certain subgroups were significantly benefited; greater gain in stroke-free survival was observed in younger, male patients, as well as those exhibiting lower baseline folate concentrations, higher baseline systolic blood pressure, higher baseline total cholesterol and blood glucose, and with MTHFR (methylenetetrahydrofolate reductase) C677T CT or TT genotype.

• See Also: Association between central blood pressure and subclinical cerebrovascular disease in older adults

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