Saturday, January 25, 2020

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

So maybe statins aren't that bad.  But it doesn't say what dose is needed, so get your doctor to find that out.  Yes, this is in rats but your stroke medical professionals should have found out that answer for humans. At least if they were competent. 17 years to become competent in that, that should be enough time for even the slowest.

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

First published: 27 May 2003
Citations: 383





Abstract

We demonstrate that the 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors atorvastatin and simvastatin enhance functional outcome and induce brain plasticity when administered after stroke to rats. With atorvastatin treatment initiated 1 day after stroke, animals exhibited significant increases in vascular endothelial growth factor, cyclic guanosine monophosphate, angiogenesis, endogenous cell proliferation and neurogenesis, and an increase in the synaptic protein, synaptophysin. Atorvastatin‐induced angiogenesis in a tube formation assay was reduced by an antibody against the vascular endothelial growth factor receptor 2 (FIK‐1) and by the nitric oxide synthase inhibitor, N‐mono‐methyl‐L‐arginine (L‐NAME). Atorvastatin also induced phosphorylation of Akt and Erk in cultured primary cortical neurons. These data indicate that atorvastatin induced brain plasticity and has neurorestorative activity after experimental stroke. Ann Neurol 2003


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