Wednesday, February 5, 2020

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Your doctor has two responsibilities post stroke. Does she pass or fail?

1. Give you this test.

2. Have protocols that prevent dementia if you don't pass this test.  

Your chances of getting dementia.



1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.





2. Then this study came out and seems to have a range from 17-66%. December 2013.





3. A 20% chance in this research.   July 2013.





4. Dementia Risk Doubled in Patients Following Stroke September 2018 





5. Parkinson’s Disease May Have Link to Stroke March 2017

The latest here:

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study





Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer’s dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer’s dementia cases and controls. APOE2/2 was associated with a low Alzheimer’s dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and controls. Finding and targeting the factors by which APOE and its variants influence Alzheimer’s disease could have a major impact on the understanding, treatment and prevention of the disease.

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