Genes associated with inflammation may serve as biomarkers for the diagnosis of coronary artery disease and ischaemic stroke

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Genes associated with inflammation may serve as biomarkers for the diagnosis of coronary artery disease and ischaemic stroke

Lipids in Health and Disease — Zheng PF, Liao FJ, Yin RX, et al. | March 17, 2020

In the present study, the researchers sought to identify genes and pathways involved in coronary artery disease (CAD) and ischaemic stroke (IS) and related mechanisms. Two array CAD datasets of (GSE66360 and GSE97320) and an array IS dataset (GSE22255) have been downloaded. Using the limma package, differentially expressed genes (DEGs) were identified. In total, 20 common DEGs (all upregulated) were identified between the CAD/IS and control groups. The top 5 high degree genes, including Jun proto-oncogene (JUN, degree = 9), C-X-C motif chemokine ligand 8 (CXCL8, degree = 9), tumour necrosis factor (TNF, degree = 9), suppressor of cytokine signalling 3 (SOCS3, degree = 8) and TNF alpha induced protein 3 (TNFAIP3, degree = 8) were noted following MCODE analysis. Findings suggested that the inflammation-related CXCL8, TNF, SOCS3 and TNFAIP3 can serve as biomarkers for CAD or IS diagnosis. Possible mechanisms can include Toll-like receptor, TNF, NF-kappa B, cytokine-cytokine receptor interactions and the NOD-like receptor signalling pathways.

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