I have no clue what this is trying to say or what possible use for stroke recovery.
Medium- and long-term functional behavior evaluations in an experimental focal ischemic stroke mouse model
Cognitive Neurodynamics
(2020)
Abstract
Cerebrovascular
accident (CVA) is one of the leading causes of death and disability
worldwide, as well as a major financial burden for health care systems.
CVA rodent models provide experimental support to determine possible in
vivo therapies to reduce brain injury and consequent sequelae. This
study analyzed nociceptive, motor, cognitive and mood functions in mice
submitted to distal middle cerebral artery (DMCA) occlusion. Male C57BL
mice (n = 8) were randomly allocated to control or DMCA groups. Motor
function was evaluated with the tests: grip force, rotarod and open
field; and nociceptive threshold with von Frey and hot plate
assessments. Cognitive function was evaluated with the inhibitory
avoidance test, and mood with the tail suspension test. Evaluations were
conducted on the seventh- and twenty-eighth-day post DMCA occlusion to
assess medium- and long-term effects of the injury, respectively. DMCA
occlusion significantly decreases muscle strength and spontaneous
locomotion (p < 0.05) both medium- and long term; as well as increases immobility in the tail-suspension test (p < 0.05),
suggesting a depressive-type behavior. However, DMCA occlusion did not
affect nociceptive threshold nor cognitive functions (p > 0.05).
These results suggest that, medium- and long-term effects of DMCA
occlusion include motor function impairments, but no sensory
dysfunction. Additionally, the injury affected mood but did not hinder
cognitive function.
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