Mechanisms of neurite repair

This is absolutely key to your recovery. If your doctor does nothing with this you need to report him/her for medical malpractice.  We need neurite outgrowth and axon pathfinding to reconnect our damaged neurons, probably even more important for TBI patients. 

Mechanisms of neurite repair

Author links open overlay panelHan-HsuanLiuYuh-NungJan

https://doi.org/10.1016/j.conb.2020.02.010Get rights and content

Under a Creative Commons license

open access

Highlights

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Reactivate intrinsic growth programs after injury can promote neurite repair.

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Repair of secondary damage upon injury is critical for full functional recovery.

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Combination of pro-regeneration factors can enhance neurite repair.

Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that serve as key regulators to initiate neurite repair and intrinsic signaling pathways and transcriptional and post-transcriptional factors that facilitate neurite repair. We also touch upon reports on how dendrites may be affected upon axotomy and how the regeneration potential in injured neurites might be maximized.

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Previous article in issue

Current Opinion in Neurobiology 2020, 63:53–58

This review comes from a themed issue on Cellular neuroscience

Edited by Thomas Schwarz and Holly Cline

https://doi.org/10.1016/j.conb.2020.02.010

0959-4388/© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).