Saturday, April 4, 2020

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

Maybe you want to see what human research followup and protocols your doctors created from this in the past four and a half years.  Or you could let the incompetent sleeping dogs lie.  Your choice, it will just impact how well your children and grandchildren recover from a stroke.

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

2015 Oct 27;6:8466. doi: 10.1038/ncomms9466.

Abstract

As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood-brain barrier and altered neuronal activity, might lead to structural and functional rejuvenation of the aged brain. Here we show that a 6-week treatment of young (4 months) and old (20 months) rats with montelukast, a marketed anti-asthmatic drug antagonizing leukotriene receptors, reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals. By using gene knockdown and knockout approaches, we demonstrate that the effect is mediated through inhibition of the GPR17 receptor. This work illustrates that inhibition of leukotriene receptor signalling might represent a safe and druggable target to restore cognitive functions in old individuals and paves the way for future clinical translation of leukotriene receptor inhibition for the treatment of dementias.
PMID:
26506265
PMCID:
PMC4639806
DOI:
10.1038/ncomms9466
[Indexed for MEDLINE]
Free PMC Article

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