Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,372 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Thursday, May 28, 2020
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins
Great, now we just need EXACT PROTOCOLS SO WE CAN DELIVER GDNF TO OUR BRAINS. When the fuck will you provide that answer? Since it will be never, I'm looking here for clues, I'm not medically trained so don't do this on your own.
regulates axonal outgrowth and repulsive guidance molecules.
Abstract
Owing
to its potent longterm neuroprotective and neurorestorative properties,
glial cell line-derived neurotrophic factor (GDNF) is currently studied
in neurodegenerative disease clinical trials. However, little is known
about the longterm effect of GDNF on neurological recovery, brain
remodeling and neuroplasticity in the post-acute phase of ischemic
stroke. In a comprehensive set of experiments, we examined the effects
of lentiviral GDNF administration after ischemic stroke. GDNF reduced
neurological deficits, neuronal injury, blood-brain barrier permeability
in the acute phase in mice. As compared with control, enhanced
motor-coordination and spontaneous locomotor activity were noted in
GDNF, which were associated with increased microvascular remodeling,
increased neurogenesis and reduced glial scar formation in the
peri-infarct tissue. We observed reduced brain atrophy and increased
plasticity of contralesional pyramidal tract axons that crossed the
midline in order to innervate denervated neurons in the ipsilesional red
and facial nuclei. Contralesional axonal plasticity by GDNF was
associated with decreased abundance of the axonal growth inhibitors
brevican and versican in contralesional and ipsilesional brain tissue,
reduced abundance of the growth repulsive guidance molecule ephrin b1 in
contralesional brain tissue, increased abundance of the midline growth
repulsive protein Slit1 in contralesional brain tissue and reduced
abundance of Slit1's receptor Robo2 in ipsilesional brain tissue. These
data indicate that GDNF potently induces longterm neurological recovery,
peri-infarct brain remodeling and contralesional neuroplasticity, which
are associated with the fine-tuned regulation of axonal growth
inhibitors and guidance molecules that facilitate the growth of
contralesional corticofugal axons in the direction to the ipsilesional
hemisphere.
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