Friday, May 22, 2020

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

What EXACT PROTOCOL is your doctor prescribing to remove this cerebral atherosclerosis? Research is 13 and 20 years old, how come your doctor has done nothing in that amount of time? How fucking incompetent is your doctor and hospital? A serious question; ask them!

I'm using watermelon  but since there is no clinical study on it, I'm just guessing on amounts.

Watermelon juice reverses hardening of the arteries  Nov. 2011 

Another here:

Hebrew University Researcher Finds 'Sweet' Way To Help Prevent Heart Disease, fruit known in Hebrew as pomelit December 2004 

The latest here:

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain





Abstract

Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer’s disease, suggesting shared mechanisms.

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Data availability

Phenotype data are available at: https://www.radc.rush.edu. Proteomic data from the discovery dataset (ROS/MAP cohorts) are available at https://www.synapse.org/#!Synapse:syn17015098. Proteomic data from the replication dataset (BLSA cohort) are available at https://www.synapse.org/#!Synapse:syn11209141.

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