Thursday, July 2, 2020

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis

You mean this from March 2015 wasn't good enough?

But you need to know none of this since your doctor will know about this study from March 2015 and have already updated your drug taking protocols. 

Where Can I Find A List of Anticholinergic Drugs?

 

Notice that baclofen, Tizanidine (Zanaflex) and Zantac may have some anticholinergic activity.

Cumulative Use of Strong Anticholinergics and Incident Dementia March 2015

The latest here:

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis


Pieper NT, Grossi CM, Chan WY, et al
Age and Aging|July 1, 2020
A systematic review and meta-analysis was performed to examine the link between anticholinergic drugs and the risk of dementia, mild cognitive impairment and cognitive decline among older people, to ultimately clarify the long-term impact of anticholinergic drugs on cognitive function. For this purpose, the relevant studies with ≥12 weeks follow-up, published between January 2002 and April 2018, were identified. This analysis included 26 studies with 621,548 participants. Findings from observational studies showed increased dementia incidence and cognitive decline in correlation with anticholinergic drug use. Since studies were observational with considerable risk of bias, so, experts could not conclude a causal link. To guide the management of long-term use, stronger evidence from high-quality studies is required.
Read the full article on Age and Aging.

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