Tuesday, September 29, 2020

Greater Occipital Nerve Stimulation Boosts Associative Memory in Older Individuals: A Randomized Trial

Just maybe you want this post stroke. Ask your doctor for this. No knowledge, the board of directors needs to be fired, the buck stops at the board of directors, they are responsible for not setting correct goals for the stroke department.

Greater Occipital Nerve Stimulation Boosts Associative Memory in Older Individuals: A Randomized Trial

First Published September 23, 2020 Research Article 

Transcutaneous electrical stimulation (tES) is a new approach that aims to stimulate the brain. Recently, we have developed tES approaches to enhance plasticity that modulate cortical activity via the greater occipital nerve (ON) in a “bottom-up” way. Thirty subjects between the ages of 55 and 70 years were enrolled and tested using a double-blind, sham-controlled, and randomized design. Half of the participants received active stimulation, while the other half received sham stimulation. Our results demonstrate that ON-tES can enhance memory in older individuals after one session, with effects persisting up to 28 days after stimulation. The hypothesized mechanism by which ON-tES enhances memory is activation of the locus coeruleus–noradrenaline (LC-NA) pathway. It is likely that this pathway was activated after ON-tES, as supported by observed changes in α-amylase concentrations, a biomarker for noradrenaline. There were no significant or long-lasting side effects observed during stimulation. Clinicaltrial.gov (NCT03467698).

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