Saturday, September 19, 2020

Statins use and outcome of acute ischemic stroke patients after systemic thrombolysis

You mean it is not a standard protocol to give statins post stroke to improve recovery? 

Statins.

tested in rats from 2003

http://Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke  

Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice

Or,

Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons 

October 2012

tested in humans, March, 2011

http://www.medwirenews.com/39/91658/Stroke/Acute_statin_therapy_improves_survival_after_ischemic_stroke.html

And now lost even to the Wayback Machine

So I think this below is the actual research;

Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke April 2011

The latest here:

Statins use and outcome of acute ischemic stroke patients after systemic thrombolysis

 
Mowla A, Shah H, Lail NS, et al
Cerebrovascular Diseases|September 15, 2020

This retrospective review was undertaken to determine the impacts of statins and their intensity on symptomatic intracranial hemorrhage (sICH) and result following IV thrombolysis (IVT) for acute ischemic stroke (AIS). For all the patients managed with IVT for AIS during a 10-year span, the medical records and cerebrovascular images were analyzed. Comparison was performed between statin users vs non-users and also between high-intensity vs low-intensity groups, in terms of safety and discharge modified Rankin Score. Findings demonstrated no significant link between risk of sICH and poor outcome post-IVT for patients on prior statin treatment. There was no significant link between the risk of sICH and poor result following IVT and the intensity of the stain employed.

Read the full article on Cerebrovascular Diseases.

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