Post-stroke
depression and executive dysfunction co-occur and are highly
debilitating. Few treatments alleviate both depression and executive
dysfunction after stroke. Understanding the brain network changes
underlying post-stroke depression with executive dysfunction can inform
the development of targeted and efficacious treatment. In this review,
we synthesize neuroimaging findings in post-stroke depression and
post-stroke executive dysfunction and highlight the network
commonalities that may underlie this comorbidity. Structural and
functional alterations in the cognitive control network, salience
network, and default mode network are associated with depression and
executive dysfunction after stroke. Specifically, post-stroke depression
and executive dysfunction are both linked to changes in intrinsic
functional connectivity within resting state networks, functional
over-connectivity between the default mode and salience/cognitive
control networks, and reduced cross-hemispheric frontoparietal
functional connectivity. Cognitive training and noninvasive brain
stimulation targeted at these brain network abnormalities and specific
clinical phenotypes may help advance treatment for post-stroke
depression with executive dysfunction.
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