Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,397 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Friday, November 13, 2020
The Bioactivity of Neuronal-Derived Nitric Oxide in Aging and Neurodegeneration: Switching Signaling to Degeneration
What the fuck is this trying to say? Nitric oxide is extremely useful in relaxing the blood vessels and reducing blood pressure. Should I be taking foods that
create nitric oxide? What? How much? How often? Answers to those
questions are what we need researchers to focus on. AND THAT IS WHY WE NEED SURVIVORS IN CHARGE.
Changes in the bioactivity of .•NO
are central to the molecular pathways associated with brain aging and
neurodegeneration, including neurometabolism, neurovascular coupling and
neuroinflammation;
•
Bioactivity of .•NO is shaped by the redox milieu in cells and tissues;
•
Monitoring .•NO concentration Dynamics in brain tissue and in vivo can be achieved using electrochemical methods coupled to microelectrodes.
Abstract
The small and diffusible free radical nitric oxide (•NO)
has fascinated biological and medical sciences since it was promoted
from atmospheric air pollutant to biological ubiquitous signaling
molecule. Its unique physical chemical properties expand beyond its
radical nature to include fast diffusion in aqueous and lipid
environments and selective reactivity in a biological setting determined
by bioavailability and reaction rate constants with biomolecules. In
the brain, •NO is recognized as a key player in numerous
physiological processes ranging from neurotransmission/neuromodulation
to neurovascular coupling and immune response. Furthermore, changes in
its bioactivity are central to the molecular pathways associated with
brain aging and neurodegeneration. The understanding of •NO
bioactivity in the brain, however, requires the knowledge of its
concentration dynamics with high spatial and temporal resolution upon
stimulation of its synthesis. Here we revise the understanding of the
role of neuronal-derived •NO in brain physiology, aging and
degeneration, focused on changes in the extracellular concentration
dynamics of this free radical and the regulation of bioenergetic
metabolism and neurovascular coupling.(Nothing here told us anything useful at all, What the fuck were you thinking when you wrote these lines?)
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