Wednesday, December 16, 2020

Identifying large ischemic core volume ranges in acute stroke that can benefit from mechanical thrombectomy

 Once again it is YOUR RESPONSIBILITY  to have the correct stroke so your doctors can treat you properly. One would think it is the doctor's responsibility to be able to treat all strokes, but no, you better plan ahead to have the correct treatable stroke. Regardless, nothing here even remotely suggests you will get 100% recovered.

Identifying large ischemic core volume ranges in acute stroke that can benefit from mechanical thrombectomy

  1. Takeshi Yoshimoto1,
  2. Manabu Inoue2,3,
  3. Kanta Tanaka2,
  4. Kodai Kanemaru3,
  5. Junpei Koge3,
  6. Masayuki Shiozawa3,
  7. Naruhiko Kamogawa3,
  8. Shunsuke Kimura3,
  9. Tetsuya Chiba3,
  10. Tetsu Satow4,
  11. Jun C Takahashi4,
  12. Kazunori Toyoda3,
  13. Masatoshi Koga3,
  14. Masafumi Ihara1

Author affiliations

Abstract

Background We aimed to identify the large ischemic core (LIC) volume ranges in acute ischemic stroke patients that can benefit from mechanical thrombectomy (MT).

Methods Consecutive patients within 24 hours of onset of anterior circulation ischemic stroke with large vessel occlusion and ischemic core volumes of 70–300 mL were included from our single-center prospective database from March 2014 to December 2019. Subjects were divided into three groups by baseline ischemic core volume (A: 70–100 mL; B: 101–130 mL; C: >130 mL). We compared modified Rankin Scale (mRS) score 0–2 at 3 months and parenchymal hematoma between patients receiving MT and standard medical treatment (SMT), and determined clinically treatable core volume ranges for MT.

Results Of 157 patients (86 women; median age, 81 years; median ischemic core volume, 123 mL), 49 patients underwent MT. In Group A (n=52), MT patients (n=31) showed a higher proportion of mRS 0–2 at 3 months (52% vs 5%, P<0.05) versus SMT, respectively. Group B (n=36) MT patients (n=14) also had a higher proportion of mRS 0–2 at 3 months (29% vs 9%, P=0.13) versus SMT, respectively. In Group C (n=69), only four patients received MT. The 95% confidence intervals for the probability of mRS 0–2 at 3 months in patients with MT (n=49) versus SMT (n=108) intersected at 120–130 mL.

Conclusions Ischemic core volumes between 70 and 100 mL may benefit from MT. The treatable upper core limit is approximately 120 mL in selected patients with LIC of 70–300 mL.(You'll want to make sure your stroke is in these ranges, otherwise you're screwed.)

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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