POTENTIAL ROLE OF EXOSOME IN POST-STROKE REORGANIZATION AND/OR NEURODEGENERATION

I have 10 posts on exosomes back to March, 2011. Your doctors can explain their incompetency in not getting researchers to followup and create translation interventions from them.

 

 POTENTIAL ROLE OF EXOSOME IN POST-STROKE REORGANIZATION AND/OR NEURODEGENERATION

Fateme Azizi1 , Sahar Askari2 , Pegah Javadpour2 , Mahmoudreza Hadjighassem1,4,* , Rasoul Ghasemi2,3,* 1 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2 Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4 Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran * Corresponding authors: Rasoul Ghasemi, Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran and Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Chamran highway, Velenjak, Tehran, Iran, Phone: + 98 21 22439971, E-mail: Rghasemi60@sbmu.ac.ir; r_ghasemi60@yahoo.com Mahmoudreza Hadjighassem MD, Ph.D., Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. E-mail: mahmoudreza@hotmail.com http://dx.doi.org/10.17179/excli2020-3025 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). 

ABSTRACT 

Currently, stroke is a common and devastating condition, which is sometimes associated with permanent cerebral damages. Although in early time after stroke, the related treatments are mainly focused on the restoration of cerebral blood flow (CBF), at the same time, some changes are commencing that continue for a long time and need to be specially noticed. Previous studies have proposed several molecular mechanisms in these post-stroke events. Exosomes are a type of vesicle, which are formed and secreted by most cells as a mean to transfer cellular constituents such as proteins, DNA and/or RNA to distant cells. Therefore, they are considered as a novel mechanism of cellular communication. Herein, we reviewed the current knowledge on cascades, which are activated after stroke and consequently lead to the reorganization and/or continuance of tissue damage and development of other disorders such as Neurodegenerative diseases (ND). Thereafter, we summarized the latest proofs about the possible participation of exosomes in transferring some components such as proteins and micro-RNAs (miRs), from the affected areas to other parts of the brain and eventually cause the above-mentioned post-stroke events.