Saturday, February 6, 2021

Class-3 semaphorins: Potent multifunctional modulators for angiogenesis-associated diseases

So nothing useful came out of this review. You might want your doctors and hospital actually contact researchers to get human research going. We need angiogenesis to supply blood  to new neurons and those in the penumbra.  

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature by processes of sprouting and splitting.

Class-3 semaphorins: Potent multifunctional modulators for angiogenesis-associated diseases

Under a Creative Commons license
open access

Highlights

SEMA3 is considered as a vital regulator involved in angiogenesis.

Several SEMA3 subtypes play a dual role in pathological angiogenesis.

Whether SEMA3 promotes or inhibits neovascularization depends on target cell.

SEMA3 can be a novel therapeutic target for angiogenesis-associated diseases.

Abstract

Semaphorins, the neuronal guidance cues, were shown to have broad influences on pathophysiological processes such as bone remodeling, immune responses, and angiogenesis. In particular, Class-3 Semaphorins (SEMA3) is considered a vital regulator involved in angiogenesis. Scientific evidence has pointed to the role of angiogenesis in many diseases, and numerous efforts have been made to explore the possibilities of curing those diseases by targeting angiogenesis. Nevertheless, the efficacies are limited owing to the complex mechanisms of angiogenesis. Hence, investigating the mechanisms of SEMA3 in angiogenesis may contribute to novel therapeutics for diseases. Previous reviews mainly focused on the various functions of semaphorins in one particular disease, and the specific angiogenesis mechanism of SEMA3 in diverse diseases has not been well elucidated. Additionally, the role of SEMA3 in angiogenesis remains elusive, as contradicting results have been found in different disease types. Some evidence from recent studies implies that, while most SEMA3 molecules inhibit pathological angiogenesis in different diseases, occasionally SEMA3 may also promote angiogenesis. This review summarizes the specific role of SEMA3 in a variety of angiogenesis-associated diseases, and documents SEMA3 may be a promising therapeutic target for treating angiogenesis-associated diseases.

 
 

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