Thursday, March 25, 2021

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

 Make sure your doctor doesn't go over this critical level of antibiotics. She'll have to translate this from mouse size to your human size.

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

Under a Creative Commons license
open access
Referred to by
Kuti Baruch, Michal Schwartz
Circulating Monocytes in between the Gut and the Mind
Cell Stem Cell, Volume 18, Issue 6, 2 June 2016, Pages 689-691

Highlights

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Antibiotics decrease neurogenesis and cognitive function

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Probiotics or exercise rescues neurogenesis and cognitive function

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Ly6Chi monocytes are crucial for brain homeostasis

Summary

Antibiotics, though remarkably useful, can also cause certain adverse effects. We detected that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention. Reconstitution with normal gut flora (SPF) did not completely reverse the deficits in neurogenesis unless the mice also had access to a running wheel or received probiotics. In parallel to an increase in neurogenesis and memory retention, both SPF-reconstituted mice that ran and mice supplemented with probiotics exhibited higher numbers of Ly6Chi monocytes in the brain than antibiotic-treated mice. Elimination of Ly6Chi monocytes by antibody depletion or the use of knockout mice resulted in decreased neurogenesis, whereas adoptive transfer of Ly6Chi monocytes rescued neurogenesis after antibiotic treatment. We propose that the rescue of neurogenesis and behavior deficits in antibiotic-treated mice by exercise and probiotics is partially mediated by Ly6Chi monocytes.

 
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