Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,42 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Subarachnoid hemorrhage (SAH) secondary to rupture of an intracranial aneurysm (IA) is a devastating condition with high morbidity and mortality. Individuals with a positive family history of aneurysmal SAH (aSAH) or IA can have an increased risk for aSAH or IA themselves. Screening is currently recommended in families with ≥ 2 affected first degree relatives.
To assess the usefulness and cost-effectiveness of IA screening in individuals with a positive first-degree family history, relative to the number of family members affected.
We performed a systematic literature search using Pubmed and Google Scholar and identified additional studies by reviewing reference lists. Only original studies and review papers were considered. We excluded genetic diseases associated with IA and studies with unclear data concerning the number of first- versus second-degree relatives affected.
This review included 37 articles. Individuals with ≥ 2 affected first degree relatives had a higher prevalence of IA (average 13.1% vs. 3% in the general population). Similarly, we found a higher prevalence of IA in individuals with ≥ 1 affected first degree relative (average 4.8%, up to 19% in individuals with additional risk factors). The risk of aSAH was also increased in both categories. Recent studies stressed the importance of serial screening over time and suggested that such screening can be cost-effective in persons with only one first-degree relative with IA or aSAH.
While current guidelines do not recommend screening individuals with ≥ 1 first degree relative affected, we found strong arguments in favor of this approach.
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