Monday, April 26, 2021

Association between abnormal body weight and stroke outcome: A meta‐analysis and systematic review

 Maybe you want your doctor to verify that you being overweight/obese should be accomplished before your next stroke, not after. I was at exactly 25 BMI prior to stroke, then gained 30 pounds because my doctor knew nothing and did nothing to get me recovered enough to continue with all the activities that kept me in shape.

Association between abnormal body weight and stroke outcome: A meta‐analysis and systematic review

First published: 25 April 2021

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ene.14881

Abstract

Background

To test the hypothesis that “obesity paradox” exists in stroke patients, we conducted a meta‐analysis and systematic review on the association between abnormal body weight (obesity, overweight, or underweight) and the outcome of different types of stroke.

Methods

This meta‐analysis and systematic review was performed in conformity to the PRISMA guidelines. Studies investigating the association between abnormal body weight and the outcome of different types of stroke were searched in PubMed and Embase databases from their inception to March 20, 2021.

Results

33 articles including 84,660 patients were included in this study. Obesity and overweight were associated with longer survival in mixed‐stroke patients (acute ischemic stroke [AIS] combined with one or more other stroke subtypes) than was normal weight, while underweight was related to shorter survival; the pooled hazard ratios (HRs) of mortality were 0.77 (95% confidence interval [CI]: 0.71 to 0.83) for obesity, 0.76 (95% CI: 0.72‐0.80) for overweight, and 1.71 (95% CI: 1.56‐1.87) for underweight. However, only obesity was associated with longer survival in AIS patients compared with normal weight, and underweight was related to shorter survival; the pooled HR of mortality was 0.75 (95% CI: 0.64‐0.88) for obesity and 1.53 (95% CI: 1.27‐1.85) for underweight. After merging mixed‐stroke and AIS patients, we got similar results as in mixed‐stroke patients.

Conclusions

Our results suggested that in patients with mixed‐stroke or AIS, obesity was associated with a longer survival time than normal weight, while underweight was associated with a shorter survival time.

 

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