Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,372 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Saturday, April 17, 2021
Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease
Because of the usefulness of nitric oxide in your recovery, your doctor is responsible for adjusting your nitric oxide protocol with this in mind. Or does your doctor incompetently not even have a nitric oxide protocol?
The
molecular mechanisms underlying the degeneration and neuronal death
associated with Parkinson's disease (PD) are not clearly understood.
Several pathways and models have been explored in an overwhelming number
of studies. Overall, from these studies, mitochondrial dysfunction and
nitroxidative stress have emerged as major contributors to degeneration
of dopaminergic neurons in PD. In addition, an excessive or
inappropriate production of nitric oxide (•NO) and an abnormal metabolism of dopamine have been independently implicated in both processes. However, the participation of •NO
in reactions with dopamine relevant to neurotoxicity strongly suggests
that dopamine or its metabolites may be potential targets for •NO, affecting the physiological chemistry of both, •NO
and dopamine. In this short review, we provide a critical and
integrative appraisal of the nitric oxide-dopamine pathway we have
previously suggested and that might be operative in PD. This pathway
emphasizes a connection between abnormal dopamine and •NO
metabolism, which may potentially converge in an integrated mechanism
with toxic cellular outcomes. In particular, it encompasses the
synergistic interaction of •NO with 3,4-dihydroxyphenylacetic
acid (DOPAC), a major dopamine metabolite, leading to dopaminergic cell
death via mechanisms that involve mitochondrial dysfunction,
gluthathione depletion and nitroxidative stress.
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