Combination of serum neurofilament light chain levels and MRI markers to predict cognitive function in ischemic stroke

 Describes a problem, OFFERS NO SOLUTION. USELESS.

But then your doctor should have already been doing something about this for 2.75 years already.

Serum neurofilament light - A biomarker of neuroaxonal injury after ischemic stroke October 2018 

I'd suggest firing the board of directors since they are obviously not setting the correct goals for your stroke hospital. 100% recovery  for all is the only goal in stroke, the status quo is a complete failure and only YOU can change that trajectory.

 

The latest here:

 

 Combination of serum neurofilament light chain levels and MRI markers to predict cognitive function in ischemic stroke

Neurorehabilitation and Neural Repair , Volume 35(3) , Pgs. 247-255.

NARIC Accession Number: J86118.  What's this?
ISSN: 1545-9683.
Author(s): Peng, Yuan ; Li, Qianfeng ; Qin, Lei ; He, Yating ; Luo, Xun ; Lan, Yue ; Chen, Xin ; Wang, Xin ; Wang, Qing M..
Publication Year: 2021.
Number of Pages: 9.

Abstract: 

Study assessed the association of serum neurofilament light chain (NfL) levels and neuroimaging markers with poststroke cognitive outcome. A total of 1,028 patients were screened; among them, 144 patients with acute ischemic stroke (stroke group) and 30 patients without stroke (control group) were enrolled. Serum NfL levels of samples obtained from both groups were measured through single molecule array assay. Neuroimaging markers of neuroaxonal injury, including infarct volume and white matter hyperintensities (WMH) in the stroke group were quantified on magnetic resonance images. The primary outcome was the Functional Independence Measure (FIM) cognitive subscores on discharge. The prognosis value of the combination of serum NfL levels and imaging markers for predicting FIM cognitive subscores on discharge was calculated using the area under curve (AUC) of the receiver operating characteristic. Serum NfL levels of the stroke group were 9-fold higher than those of the control group. There was a correlation of serum NfL levels with infarct volume and functional outcome, including FIM cognitive subscores and FIM motor subscores on admission, but not with WMH volume after adjusting for infarct volume. Serum NfL levels on admission independently predicted poststroke FIM cognitive subscores on discharge (AUC = 0.672). The predictive(What? No solution? You're that fucking useless?) value for poststroke cognitive outcome was improved by combining serum NfL levels with infarct and WMH volume (AUC = 0.760). The combination of serum NfL levels with volume of infarct and WMH shows an improved predictive value for cognitive function during acute rehabilitation phase after stroke, providing a promising panel of biomarkers for prognosis and guidance of treatment.
Descriptor Terms: BIOCHEMISTRY, BRAIN, COGNITION, FUNCTIONAL EVALUATION, IMAGING, OUTCOMES, PREDICTION, STROKE.


Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Peng, Yuan , Li, Qianfeng , Qin, Lei , He, Yating , Luo, Xun , Lan, Yue , Chen, Xin , Wang, Xin , Wang, Qing M.. (2021). Combination of serum neurofilament light chain levels and MRI markers to predict cognitive function in ischemic stroke.  Neurorehabilitation and Neural Repair , 35(3), Pgs. 247-255. Retrieved 5/18/2021, from REHABDATA database.