Calorie restriction can modulate the gut microbiota and protect against many diseases including ischemic stroke.
However, the role of calorie-restriction-induced microbiota alteration
remained unknown in ischemic stroke rehabilitation. Here we conducted
30% reduction of caloric intake on mice for four weeks, to evaluate its
role on ischemic stroke rehabilitation. Significantly, this calorie
restriction led to better long-term rehabilitation in comparison of
normal control. Notably, the transplantation of gut microbiome
from calorie-restriction-treated mice to post-stroke mice was eligible
to obtain better long-term rehabilitation of stroke mice. Bifidobacterium identified by 16 S ribosomal RNA sequencing were enriched in those of calorie-restriction mice. Then we administrated Bifidobacterium to stroke mice and found Bifidobacterium
treatment could successfully improve the long-term rehabilitation of
cerebral ischemia mice. Furthermore, the metabolomics analysis revealed a
panel of upshifting metabolites, suggesting that calorie restriction
greatly altered the gut microbiota
composition and its metabolism. Hence, we discovered the novel effect
of CR on long-term rehabilitation of ischemic stroke and the underlying
role of gut microbiota, which might provide novel thoughts for the
clinical post-stroke rehabilitation.
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