Plasma β-Amyloid in Mild Behavioural Impairment – Neuropsychiatric Symptoms on the Alzheimer’s Continuum

With your risk of dementia post stroke your doctor should have this test be a protocol to establish a baseline for you.

If found then your doctor needs to prescribe the dementia prevention protocols that they have already assembled. If s/he doesn't have any call the president and ask when competent people will be hired to create them.  Hopefully in time for your children and grandchildren to use.

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018 

The latest here:

 

Plasma β-Amyloid in Mild Behavioural Impairment – Neuropsychiatric Symptoms on the Alzheimer’s Continuum

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Ruxin Miao, Hung-Yu Chen, PhD, Sascha Gill, MSc, ...

First Published May 26, 2021 Research Article 

https://doi.org/10.1177/08919887211016068

Article information

Abstract

Introduction:

Simple markers are required to recognize older adults at higher risk for neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) have been independently implicated in the development of incident cognitive decline and dementia. Here we studied the associations between MBI and plasma Aβ₄₂/Aβ₄₀.

Methods:

Participants with normal cognition (n = 86) or mild cognitive impairment (n = 53) were selected from the Alzheimer’s Disease Neuroimaging Initiative. MBI scores were derived from Neuropsychiatric Inventory items. Plasma Aβ₄₂/Aβ₄₀ ratios were assayed using mass spectrometry. Linear regressions were fitted to assess the association between MBI total score as well as MBI domain scores with plasma Aβ₄₂/Aβ₄₀.

Results:

Lower plasma Aβ₄₂/Aβ₄₀ was associated with higher MBI total score (p = 0.04) and greater affective dysregulation (p = 0.04), but not with impaired drive/motivation (p = 0.095) or impulse dyscontrol (p = 0.29) MBI domains.

Conclusion:

In persons with normal cognition or mild cognitive impairment, MBI was associated with low plasma Aβ₄₂/Aβ₄₀. Incorporating MBI into case detection may help capture preclinical and prodromal Alzheimer’s disease.

Keywords Alzheimer’s disease, mild behavioural impairment, beta-amyloid, neuropsychiatric symptoms

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