Nanoparticle Drug-Delivery System Developed to Treat Brain Disorders

 You mean stroke leadership completely fucking failed at putting together magnetic nanoparticles delivering smaller loads of tPA resulting in much less chance of bleeds?

We should have been using magnetic nanoparticles to deliver tPA for years.

Maybe this solution from March, 2015

Magnetic nanoparticles could stop blood clot-caused strokes

Or this from  May, 2012

Future of med devices: Nanorobots in your blood stream

The latest here:

Nanoparticle Drug-Delivery System Developed to Treat Brain Disorders

Summary: A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer’s and other neurodegenerative disorders.

Source: Brigham and Women’s Hospital

In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brain barrier (BBB) and into the brain.

To facilitate successful delivery of therapeutic agents to the brain, a team of bioengineers, physicians, and collaborators at Brigham and Women’s Hospital and Boston Children’s Hospital created a nanoparticle platform, which can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact BBB.

In a mouse model of traumatic brain injury (TBI), they observed that the delivery system showed three times more accumulation in brain than conventional methods of delivery and was therapeutically effective as well, which could open possibilities for the treatment of numerous neurological disorders.

Findings were published in Science Advances.