But this has been known for years, isn't your doctor already prescribing psilocybin for you?
Psilocybin: Magic mushrooms have been found to boost neurogenesis. August 2013
Psilocybin induces time-dependent changes in global functional connectivity: Psi-induced changes in brain connectivity February 2020
The latest here:
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Published:July 05, 2021DOI:https://doi.org/10.1016/j.neuron.2021.06.008
Highlights
- •Psilocybin ameliorates stress-related behavioral deficit in mice
- •Psilocybin increases spine density and spine size in frontal cortical pyramidal cells
- •Psilocybin-evoked structural remodeling is persistent for at least 1 month
- •The dendritic rewiring is accompanied by elevated excitatory neurotransmission
Summary
Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There
are hints that the use of psychedelics can produce neural adaptations, although the
extent and timescale of the impact in a mammalian brain are unknown. In this study,
we used chronic two-photon microscopy to image longitudinally the apical dendritic
spines of layer 5 pyramidal neurons in the mouse medial frontal cortex. We found that
a single dose of psilocybin led to ∼10% increases in spine size and density, driven
by an elevated spine formation rate. The structural remodeling occurred quickly within
24 h and was persistent 1 month later. Psilocybin also ameliorated stress-related
behavioral deficit and elevated excitatory neurotransmission. Overall, the results
demonstrate that psilocybin-evoked synaptic rewiring in the cortex is fast and enduring,
potentially providing a structural trace for long-term integration of experiences
and lasting beneficial actions.
Graphical abstract
Keywords
To read this article in full you will need to make a payment
No comments:
Post a Comment