Cognitive recovery after stroke: A meta-analysis and metaregression of intervention and cohort studies

So nothing concrete on how to recover 5 lost years of brain cognition due to your stroke.

 Cognitive recovery after stroke: A meta-analysis and metaregression of intervention and cohort studies

Neurorehabilitation and Neural Repair (NNR) , Volume 35(7) , Pgs. 585-600.

NARIC Accession Number: J86909.  What's this?
ISSN: 1545-9683.
Author(s): Saa, Juan P. ; Tse, Tamara ; Baum, Carolyn M. ; Cumming, Toby ; Josman, Naomi ; Rose, Miranda ; O’Keefe, Sophie ; Sewell, Katherine ; Nguyen, Vinh ; Carey, Leeanne M..
Publication Year: 2021.
Number of Pages: 16.

Abstract: 

Study examined the short- and long-term changes in poststroke cognition and the factors that moderate these changes over time, across intervention and observational studies. Six databases were searched up to January 2020 for studies describing quantitative changes in cognition in adults with stroke. A total of 43 intervention trials and 79 observation cohorts involving 28,222 stroke participants were included. Interventions were classified into pharmacological, therapist-led, nonroutine/alternative, and usual care. Summary estimates were compared via hierarchical mixed-effects models. Age, recovery stage, stroke etiology, cognitive domain targeted in studies, and intervention types were investigated as moderators of cognition. Recovery stage and intervention were further analyzed in a multiplicative meta-regression model. Heterogeneity was significant with no evidence of publication bias. Cognitive recovery was greater in intervention trials than observational cohorts across all moderators analyzed. Nonroutine/alternative and pharmacological trials achieved the best overall results, followed by therapist-led, and usual-care interventions. Medium recovery effects were observed in examining first-ever stroke, executive function, visuo-perceptual, consciousness, and psychomotor skills, 61 to 180 days poststroke, in participants aged 65 to 70 years. Findings suggest that cognitive recovery is possible using different controlled interventions in all recovery stages, with smaller benefits 2 or more years post stroke. Longer-term studies are needed to determine the role of nonroutine/alternative therapies and the association between cognitive recovery and performance in everyday activities.
Descriptor Terms: ALTERNATIVE MEDICINE, COGNITION, INTERVENTION, LITERATURE REVIEWS, LONGITUDINAL STUDIES, OUTCOMES, PHARMACOLOGY, STROKE, THERAPY.


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Citation: Saa, Juan P. , Tse, Tamara , Baum, Carolyn M. , Cumming, Toby , Josman, Naomi , Rose, Miranda , O’Keefe, Sophie , Sewell, Katherine , Nguyen, Vinh , Carey, Leeanne M.. (2021). Cognitive recovery after stroke: A meta-analysis and metaregression of intervention and cohort studies.  Neurorehabilitation and Neural Repair (NNR) , 35(7), Pgs. 585-600. Retrieved 9/26/2021, from REHABDATA database.