Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review

All this research did was to suggest more research is needed, so this research was a total failure.

 Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review

Archives of Physical Medicine and Rehabilitation , Volume 102(8) , Pgs. 1633-1644.

NARIC Accession Number: J87026.  What's this?
ISSN: 0003-9993.
Author(s): Limaye, Neeraj S. ; Carvalho, Lilian B. ; Kramer, Sharon.
Publication Year: 2021.
Number of Pages: 12.

Abstract: 

Study summarized the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in survivors of stroke. MEDLINE, Embase, and Cochrane CENTRAL databases were searched for relevant studies using terms related to AE, neuroplasticity, brain repair, and stroke. Titles, abstracts, and selected full texts were screened by 2 independent reviewers against the following inclusion criteria: including adult survivors of stroke, completing an AE intervention working within the AE capacity, and measuring at least 1 blood biomarker outcome of interest. Two independent reviewers extracted data and assessed risk of bias using Risk of Bias in Nonrandomized Studies of Interventions and Cochrane’s Risk of Bias 2 tools. Nine studies were included, reporting on the following outcomes: brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol, interleukin 6, and myeloperoxidase. A single bout of high-intensity interval training significantly increased BDNF, IGF-1, and VEGF levels, and a 40- to 45-minute, 24-session, continuous 8-week AE training program significantly increased BDNF levels. No significant difference in response to any other AE intervention was found in other serum biomarkers. The findings suggest that AE can significantly increase BDNF, IGF-1, and VEGF across different AE protocols in survivors of stroke. However, more research is needed to determine the optimal exercise intensity and modalities, specifically in survivors of acute and subacute stroke, and how this may relate to functional outcomes.
Descriptor Terms: BIOCHEMISTRY, BRAIN, EXERCISE, LITERATURE REVIEWS, STROKE.


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Citation: Limaye, Neeraj S. , Carvalho, Lilian B. , Kramer, Sharon. (2021). Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review.  Archives of Physical Medicine and Rehabilitation , 102(8), Pgs. 1633-1644. Retrieved 9/26/2021, from REHABDATA database.