Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,372 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Developing a mathematical model to simulate the severity of HT.
Haematoma radius’ dependences on haemodynamics and geometry of the vessels are not significant.
Capillary compression has been shown a greater impact to venules than arterioles and capillary generations.
Capillary compression is able to reduce the leakage fraction of blood flow and restrain the development of a haematoma.
With
an increasingly elderly population globally, the impacts of
cerebrovascular diseases, such as stroke and dementia, become
increasingly significant. Haemorrhagic transformation (HT) is one of the
most common complications of ischaemic stroke that is caused by
dysfunction of endothelial cells in the blood-brain barrier (BBB) and
that can be exacerbated by thrombolytic therapy. Recent studies also
suggest that HT can lead to an increase in intracranial pressure (ICP)
and result in capillary compression. The aim of this study is to develop
a mathematical model that can be used to simulate the consequence of HT
over a range of vasculature length scales. We use a 2D vasculature
model to investigate the severity of HT with different vascular
geometry. The resulting model shows that the haematoma radius is
approximately constant across different length scales (100-1000um)
and in good agreement with the available experimental data. In
addition, this study identified that the effects of capillary
compression do appear to have a significant impact on the leakage
fraction of blood and hence act to restrain the development of a
haematoma.
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