Statins, Enzyme CoQ10 Supplement Use, and Cognitive Functioning

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Statins, Enzyme CoQ₁₀ Supplement Use, and Cognitive Functioning 

Brian G. Collin, MA, PhD, Dheeraj Raju, MSIE, PhD, Steven Katsikas, PhD

First Published September 8, 2021 Research Article 

https://doi.org/10.1177/08919887211044747

Article information

Abstract

Objective:

The current study assessed the effects of statin and CoQ₁₀ supplement use on changes in cognitive functioning in the Wisconsin Registry for Alzheimer’s Prevention study.

Methods:

1,573 subjects were administered medical histories, the Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Wechsler Memory Scale, Logical Memory subtest, and the Trail Making Test, Parts A (TMT-A) and B (TMT-B) 3-4 times over 5-10 years.

Results:

Linear mixed models did not yield significant effects for statin or CoQ₁₀ supplement use on changes in mental status, learning and memory, psychomotor speed, and cognitive flexibility.

Conclusions:

Statin and/or CoQ₁₀ supplement use was not associated with neuropsychological test performance in the Wisconsin Registry for Alzheimer’s Prevention study.

Keywords

statin, auditory memory, cognitive flexibility, psychomotor speed, dementia, CoQ₁₀, Alzheimer’s disease

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