This is so fucking simple to explain why stroke rehab doesn't work.
1. You have too many dead neurons; The neuronal cascade of death is causing billions of neurons to die the first week.
2. You don't know how to make neuroplasticity exactly repeatable.
3. You don't have the correct goal of 100% recovery, as a result your researchers are going for little incremental wins, not BHAGs(Big Hairy Audacious Goals.
Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them
Neurorehabilitation and Neural Repair , Volume 35(8) , Pgs. 663-679.
NARIC Accession Number: J87242. What's this?
ISSN: 1044-2073.
Author(s): Dalton, Emily J. ; Churilov, Leonid ; Lannin, Natasha A. ; Corbett, Dale ; Campbell, Bruce C. V. ; Hayward, Kathryn S..
Publication Year: 2021.
Number of Pages: 17.
Abstract: Article describes the problem of insufficient use of a systematic approach to early-phase, multidimensional dose articulation research and proposes a solution that applies this approach to design a multidimensional phase I trial to identify the maximum tolerated dose. Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajectory of recovery poststroke. The authors argue that early-phase research to systematically investigate dose is an important contributor to advance the science underpinning stroke recovery. They present a design template as a decision-support tool to increase knowledge of how to develop a phase I dose-ranging trial for nonpharmaceutical stroke recovery interventions. This solution has the potential to advance the development of efficacious stroke recovery interventions, which include activity-based rehabilitation interventions.
Descriptor Terms: HEALTH PROMOTION, INTERVENTION, REHABILITATION SERVICES, RESEARCH METHODOLOGY, SERVICE DELIVERY, STROKE.
Can this document be ordered through NARIC's document delivery service*?: Y.
Citation: Dalton, Emily J. , Churilov, Leonid , Lannin, Natasha A. , Corbett, Dale , Campbell, Bruce C. V. , Hayward, Kathryn S.. (2021). Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them. Neurorehabilitation and Neural Repair , 35(8), Pgs. 663-679. Retrieved 10/23/2021, from REHABDATA database.
NARIC Accession Number: J87242. What's this?
ISSN: 1044-2073.
Author(s): Dalton, Emily J. ; Churilov, Leonid ; Lannin, Natasha A. ; Corbett, Dale ; Campbell, Bruce C. V. ; Hayward, Kathryn S..
Publication Year: 2021.
Number of Pages: 17.
Abstract: Article describes the problem of insufficient use of a systematic approach to early-phase, multidimensional dose articulation research and proposes a solution that applies this approach to design a multidimensional phase I trial to identify the maximum tolerated dose. Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajectory of recovery poststroke. The authors argue that early-phase research to systematically investigate dose is an important contributor to advance the science underpinning stroke recovery. They present a design template as a decision-support tool to increase knowledge of how to develop a phase I dose-ranging trial for nonpharmaceutical stroke recovery interventions. This solution has the potential to advance the development of efficacious stroke recovery interventions, which include activity-based rehabilitation interventions.
Descriptor Terms: HEALTH PROMOTION, INTERVENTION, REHABILITATION SERVICES, RESEARCH METHODOLOGY, SERVICE DELIVERY, STROKE.
Can this document be ordered through NARIC's document delivery service*?: Y.
Citation: Dalton, Emily J. , Churilov, Leonid , Lannin, Natasha A. , Corbett, Dale , Campbell, Bruce C. V. , Hayward, Kathryn S.. (2021). Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them. Neurorehabilitation and Neural Repair , 35(8), Pgs. 663-679. Retrieved 10/23/2021, from REHABDATA database.
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