You'll have to ask your doctor if your brain glymphatic system was impaired from your stroke and what protocols they have to restore that system. You do expect your doctor to know EXACTLY what damage your stroke caused AND THE PROTOCOLS that will fix them. Or are you OK with your doctor's incompetence in not getting you 100% recovered? Getting you recovered is your doctor's responsibility,don't let him/her dump it on you by using the 'get out of jail free' statement: 'All strokes are different,all stroke recoveries are different.' Laugh maniacally in their face and ask them;'You expect me to believe that crapola excuse?'
Initiative to Improve Sleep and Clearance of the Brain
Summary: A new study aims to assess the usefulness of a new technology that could speed up and enhance the clearing of metabolic waste via the glymphatic system as a person sleeps.
Source: University of North Carolina
The U.S. Department of Defense is funding the first human trial of a device to speed up and enhance the natural system of brain cleansing that occurs when we sleep.
The trial will be conducted among 90 people at three trial sites – University of North Carolina, University of Washington School of Medicine, and a collaboration between Oregon Health & Science University and the Brain Electrophysiology Laboratory (BEL). Results are expected in the fall of 2022.
Recent discoveries point to the importance of quality sleep for clearance of brain metabolic waste through the newly-discovered brain glymphatic system.
If sleep is disrupted, so are these crucial processes, leading to cognitive impairment – things like faulty motor coordination, attention deficits, slower processing speed, decreased decision-making capabilities, and hampered short-term memory, in addition to increasing risk of neurodegenerative disease later in life.
These issues can have life-or-death consequences for service members in the U.S. military, which is why the Department of Defense is funding innovative research initiatives, including this three-year, $4.3-million, project with the ultimate goal of helping service members overcome acute sleep deprivation and chronic sleep restriction.
The scientists leading this effort are from UNC-Chapel Hill, the University of Washington School of Medicine, the Brain Electrophysiology Lab Oregon Health & Science University, and Montana State University.
“Our approach is to continue to validate novel imaging approaches of the human glymphatic system while assessing novel technology to improve glymphatic clearance and cognitive function,” said co-principal investigator Dawn Kernagis, PhD, assistant professor of neurosurgery at UNC School of Medicine.
“If this works, it would have major implications for service members and potentially anyone with diagnosed sleep dysfunction. It could also have implications for people with other neurological conditions, such as traumatic brain injury, Alzheimer’s disease, and other dementias.”
This project, titled “Augmented Neurophysiology of Sleep and Performance Readiness,” is part of the Medical Technology Enterprise Consortium, a collaboration between industry and academia to facilitate research and development activities, in cooperation with the U.S. Army Medical Research and Development Command and other Department of Defense agencies in the biomedical sciences to protect, treat, and optimize the health and performance of military personnel.
This effort was years in the making, starting with the discovery of the glymphatic system by co-principal investigator Jeffrey Iliff, PhD and Maiken Nedergaard, MD. In 2013, Science Magazine called it one of the Top 10 discoveries of the year.
Iliff, a professor of psychiatry and behavioral sciences and neurology at the University of Washington School of Medicine, said the biology is straightforward. Cerebral spinal fluid surrounds the brain, and as we sleep, fluid washes through brain cells and supports clearance of difference wastes. Iliff’s TED Talk on this process has been viewed more than 5 million times.
Scientists think this glymphatic function is at the heart of the restorative power of sleep. And so, scientists think disrupting sleep disrupts the glymphatic system, impairing cognition and potentially impacting long-term brain health.
“Improving glymphatic function, whether pharmacologically or by means of a device, could improve the cognitive effects of acute sleep deprivation and chronic sleep restriction,” said Iliff.. “Our lab’s research over the past eight years on brain-waste clearance in animals has helped define glymphatic biology. Now we hope to see if we can use what we’ve learned to help people overcome poor or interrupted sleep and the brain dysfunction that follows.”
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