Long-Known Music Exposure Effects on Brain Imaging and Cognition in Early-Stage Cognitive Decline: A Pilot Study

 

But I bet your doctor will do nothing with this having done nothing for over a decade. I tried getting my Mom to play big band CDs for my Dad's Parkinsons dementia but since I live two states away that was technically not possible for my Mom to accomplish.

Yes, I'm assuming this is transferable to all pre-dementia patients, including preventing dementia amongst stroke survivors.  Can your doctor make that same leap? If your stroke hospital has done nothing in the last decade you don't have a stroke hospital, why haven't you fired the board of directors?

• music (94 posts back to March 2011)

• music therapy (53 posts back to October 2014)

• musical training (13 posts back to June 2014)

Long-Known Music Exposure Effects on Brain Imaging and Cognition in Early-Stage Cognitive Decline: A Pilot Study

 

Article type: Research Article

Authors: Fischer, Corinne E.^{a; d; *} | Churchill, Nathan^{a; 1} | Leggieri, Melissa^{a; d} | Vuong, Veronica^{b; d} | Tau, Michael^c | Fornazzari, Luis R.^c | Thaut, Michael H.^{b; d; 2} | Schweizer, Tom A.^{a; d; 2}

Affiliations: [a] St. Michael’s Hospital, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Toronto, ON, Canada | [b] University of Toronto, Faculty of Music, Music and Health Science Research Collaboratory, University of Toronto, Toronto, ON, Canada | [c] Department of Psychiatry, St. Michaels Hospital, Toronto ON, Canada | [d] Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada

Correspondence: [*] Correspondence to: Corinne E. Fischer, MD, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, Room 17044 cc Wing, 30 Bond St., Toronto, Ontario, M5B 1W8, Canada. Tel.: +1 416 864 6060 /Ext 2680; E-mail: Corinne.Fischer@unityhealth.to.

Note: [1] Co-primary author.

Note: [2] Co-senior authors.

Abstract:  

Background:

Repeated exposure to long-known music has been shown to have a beneficial effect on cognitive performance in patients with AD. However, the brain mechanisms underlying improvement in cognitive performance are not yet clear. Objective:In this pilot study we propose to examine the effect of repeated long-known music exposure on imaging indices and corresponding changes in cognitive function in patients with early-stage cognitive decline. 

Methods:

Participants with early-stage cognitive decline were assigned to three weeks of daily long-known music listening, lasting one hour in duration. A cognitive battery was administered, and brain activity was measured before and after intervention. Paired-measures tests evaluated the longitudinal changes in brain structure, function, and cognition associated with the intervention. 

Results:

Fourteen participants completed the music-based intervention, including 6 musicians and 8 non-musicians. Post-baseline there was a reduction in brain activity in key nodes of a music-related network, including the bilateral basal ganglia and right inferior frontal gyrus, and declines in fronto-temporal functional connectivity and radial diffusivity of dorsal white matter. Musician status also significantly modified longitudinal changes in functional and structural brain measures. There was also a significant improvement in the memory subdomain of the Montreal Cognitive Assessment. 

Conclusion:

These preliminary results suggest that neuroplastic mechanisms may mediate improvements in cognitive functioning associated with exposure to long-known music listening and that these mechanisms may be different in musicians compared to non-musicians.

Keywords: Alzheimer’s disease, cognitive reserve, functional MRI, imaging, MRI, music

DOI: 10.3233/JAD-210610

Journal: Journal of Alzheimer's Disease, vol. 84, no. 2, pp. 819-833, 2021

Accepted 1 September 2021

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Published: 09 November 2021

Price: EUR 27.50