Tuesday, January 11, 2022

Late-life physical activity relates to brain tissue synaptic integrity markers in older adults

Now your doctor needs to get you recovered enough to do the exercise and create an EXACT PROTOCOL for the amount of exercise needed because you actually need synaptogenesis to recover from your stroke. Now comes the the chicken or egg question, which comes first? Do you need synaptogenesis to occur first so you can do the exercises or do you need to do the exercise to create synaptogenesis? Ask your doctor and not politely. She is supposed to know this crap for your recovery. No knowledge, call the president and ask when s/he will get competent persons in stroke.

 

 Synaptogenesis is the formation of synapses between neurons in the nervous system

The latest here:

Late-life physical activity relates to brain tissue synaptic integrity markers in older adults

First published: 07 January 2022

Abstract

Introduction

Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology is not well understood. Animal models indicate PA is synaptogenic. We examined the relationship between PA and synaptic integrity markers in older adults.

Methods

Four hundred four decedents from the Rush Memory and Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) and post mortem evaluation. Brain tissue was analyzed for presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, syntaxin, complexin-I, and complexin-II), and neuropathology. Models examined relationships between late-life PA (averaged across visits), and timing-specific PA (time to autopsy) with synaptic proteins.

Results

Greater late-life PA associated with higher presynaptic protein levels (0.14 < β < 0.20), except complexin-II (β = 0.08). Relationships were independent of pathology but timing specific; participants who completed actigraphy within 2 years of brain tissue measurements showed largest PA-to-synaptic protein associations (0.32 < β < 0.38). Relationships between PA and presynaptic proteins were comparable across brain regions sampled.

Discussion

PA associates with synaptic integrity in a regionally global, but time-linked nature in older adults.(What does time-linked mean?)

 

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