“Discovery consists in seeing what everyone else has seen and thinking what no one else has thought” —Albert Szent-Györgyi

 There is absolutely no discovery here. Nothing even remotely close to solving

the 5 causes of the neuronal cascade of death in the first days. Or working on creating 100% recovery protocols. In my opinion these were all worthless, tell me EXACTLY where my thinking is wrong, considering the only goal in stroke is 100% recovery.

Send me hate mail on this: oc1dean@gmail.com. I'll print your complete statement with name and my response in my blog. Or are you afraid to engage with my stroke-addled mind?

“Discovery consists in seeing what everyone else has seen and thinking what no one else has thought”

—Albert Szent-Györgyi

Progress depends on innovation. With that in mind, the journal Stroke is pleased to offer an award that is a visible and effective way of encouraging new paths, new methods and new ways of thinking. This Award is made possible by funding from the American Heart Association | American Stroke Association to whom we are grateful.

Congratulations to the recipients!

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2021

First prize: Naoki Kaneko and Sandro Satta
Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

Spotlight: Q&A with Naoki Kaneko and Sandro Satta

Second prize: Stefan J. Blaschke and Lukas Hensel
Translating Functional Connectivity After Stroke: Functional Magnetic Resonance Imaging Detects Comparable Network Changes in Mice and Humans

Spotlight: Q&A with Stefan J. Blaschke and Lukas Hensel

Third prize: Cathy S. Zhong and James Beharry
Routine Use of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

Spotlight: Q&A with Cathy S. Zhong and James Beharry

2020

First prize: Brian Mac Grory
Intravenous Fibrinolysis for Central Retinal Artery Occlusion: A Cohort Study and Updated Patient-Level Meta-Analysis

Spotlight: Q&A with Brian Mac Grory

Second prize: Tongyu Zhang and Pei Wu
Mitophagy Reduces Oxidative Stress Via Keap1 (Kelch-Like Epichlorohydrin-Associated Protein 1)/Nrf2 (Nuclear Factor-E2-Related Factor 2)/PHB2 (Prohibitin 2) Pathway After Subarachnoid Hemorrhage in Rats

Spotlight: Q&A with Tongyu Zhang and Pei Wu

Third prize: Keith L. Keene and Hyacinth I. Hyacinth
Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke

Spotlight: Q&A with Keith L. Keene and Hyacinth I. Hyacinth

2019

First prize: Shubei Ma and Jianyi Wang
Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

Spotlight: Q&A with Shubei Ma and Jianyi Wang

Second prize: Gregory Y.H. Lip
Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients: The ARISTOPHANES Study

Spotlight: Q&A with Gregory Y.H. Lip

Third prize: Frieder Schlunk
Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage

Spotlight: Q&A with Frieder Schlunk

2018

First prize: Rajkumar Verma 
Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice

Spotlight: Q&A with Rajkumar Verma

Second prize: Isaac García-Yébenes
Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

Spotlight: Q&A with Isaac García-Yébenes

Third prize: Achala Vagal
Collateral Clock Is More Important Than Time Clock for Tissue Fate: A Natural History Study of Acute Ischemic Strokes

Spotlight: Q&A with Achala Vagal

2017

First prize: Marilena Marinescu 
Cerebral Microbleeds in Murine Amyloid Angiopathy: Natural Course and Anticoagulant Effects

Spotlight: Q&A with Marilena Marinescu

Second prize: Matthew P. Pase
Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study

Spotlight: Q&A with Matthew P. Pase

Third prize: Andrew Bivard
Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke

Spotlight: Q&A with Andrew Bivard

2016

First prize: Alexis N. Simpkins 
Identification of Reversible Disruption of the Human Blood– Brain Barrier Following Acute Ischemia

Spotlight: Q&A with Alexis N. Simpkins

Second prize: Xiangrong Liu
Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

Spotlight: Q&A with Xiangrong Liu

Third prize: Gary K. Steinberg
Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study

Spotlight: Q&A with Gary K. Steinberg

2015

First prize: Kevin B. Koronowski 
Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain

Spotlight: Q&A with Kevin Koronowski

Second prize: Lucie A. van den Berg
Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke

Spotlight: Q&A with Lucie A. van den Berg

Third prize: Maurizio Paciaroni
Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study

Spotlight: Q&A with Maurizio Paciaroni

2014

First prize: Dominique A. Cadilhac 
Evaluation of Rural Stroke Services: Does Implementation of Coordinators and Pathways Improve Care in Rural Hospitals?

Spotlight: Q&A with Dr. Cadilhac

Second prize: Kristina Dupont Hougaard
Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients With Acute Ischemic Stroke: A Randomized Trial

Spotlight: Q&A with Dr. Hougaard

Third prize: Haiping Zhao
Ischemic Postconditioning Relieves Cerebral Ischemia and Reperfusion Injury Through Activating T-LAK Cell–Originated Protein Kinase/Protein Kinase B Pathway in Rats

Spotlight: Q&A with Dr. Zhao

2013

First prize: Marius de Groot and Benjamin F. J. Verhaaren
Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions

Second prize: Ya-Ling Lee
Dental Prophylaxis and Periodontal Treatment Are Protective Factors to Ischemic Stroke

Third prize: Novella Calcinaghi
Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension

2012

First prize: Julie Tilson
Characterizing and Identifying Risk for Falls in the LEAPS Study: A Randomized Clinical Trial of Interventions to Improve Walking Poststroke

Second prize: Hiroyuki Sakata
Neural Stem Cells Genetically Modified to Overexpress Cu/Zn-Superoxide Dismutase Enhance Amelioration of Ischemic Stroke in Mice

Third prize: H. Bart Brouwers
Apolipoprotein E Genotype Predicts Hematoma Expansion in Lobar Intracerebral Hemorrhage

2011

First prize: David S. Liebeskind
CT and MRI Early Vessel Signs Reflect Clot Composition in Acute Stroke

Second prize: Gary A. Ford
Intravenous Alteplase for Stroke in Those Older Than 80 Years Old

Third prize: Yu Hasegawa
Preservation of Tropomyosin-Related Kinase B (TrkB) Signaling by Sodium Orthovanadate Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats

2010

First prize: Alex Zacharek, Amjad Shehadah and Jieli Chen share first authorship
Comparison of Bone Marrow Stromal Cells Derived From Stroke and Normal Rats for Stroke Treatment

Second prize: Thomas M. Hemmen
Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L): Final Results

Third prize: J. David Spence
Treating Arteries Instead of Risk Factors: A Paradigm Change in Management of Atherosclerosis

2009

First prize: Gretchen E. Tietjen
Migraine and Biomarkers of Endothelial Activation in Young Women

Second prize: Jorge Kattah
HINTS to Diagnose Stroke in the Acute Vestibular Syndrome: Three-Step Bedside Oculomotor Examination More Sensitive Than Early MRI Diffusion-Weighted Imaging

Third prize: Nancy Mayo
A Longitudinal View of Apathy and Its Impact After Stroke

2008

First prize: Laurent Pierot
Immediate Clinical Outcome of Patients Harboring Unruptured Intracranial Aneurysms Treated by Endovascular Approach: Results of the ATENA Study

Second prize: Charlie Thompson
Living Beyond Our Physiological Means: Small Vessel Disease of the Brain Is an Expression of a Systemic Failure in Arteriolar Function: A Unifying Hypothesis

No third prize awarded.