Sunday, February 6, 2022

Mounting evidence suggests human adult neurogenesis is unlikely

 

Really? You disproved this earlier research?

Review Article on adult neurogenesis in humans April 2020 

Highlights on adult neurogenesis in humans

Investigators have confirmed that neurogenesis occurs in discrete areas of the adult brain.
This occurs primarily in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus.
Growth factors, neurotrophins, cytokines and hormones are the major regulators of adult neurogenesis.
Much progress was made over the past decade on adult neurogenesis.

 

The latest here:

Mounting evidence suggests human adult neurogenesis is unlikely

https://doi.org/10.1016/j.neuron.2022.01.004Get rights and content
Refers to
Daniel Franjic, Mario Skarica, Shaojie Ma, Jon I. Arellano, Andrew T.N. Tebbenkamp, Jinmyung Choi, Chuan Xu, Qian Li, Yury M. Morozov, David Andrijevic, Zvonimir Vrselja, Ana Spajic, Gabriel Santpere, Mingfeng Li, Shupei Zhang, Yang Liu, Joshua Spurrier, Le Zhang, Ivan Gudelj, Lucija Rapan, Hideyuki Takahashi, Anita Huttner, Rong Fan, Stephen M. Strittmatter, Andre M.M. Sousa, Pasko Rakic, Nenad Sestan
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
Neuron, Volume 110, Issue 3, 2 February 2022, Pages 452-469.e14

In this issue of Neuron, Franjic et al. (2022) use a single-nuclei RNA sequencing approach that identified signatures of adult neurogenesis in mouse, pig, and macaque dentate gyrus, but not in humans, adding to a growing body of evidence that this process is likely lost in humans.

 

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