So nothing useful came out of this research, you punted and asked for further research instead of actually creating useful protocols. Firings need to start immediately.
Effects of endovascular therapy for mild stroke due to proximal or M2 occlusions: meta-analysis
Abstract
Objective
To conduct a meta-analysis to evaluate the effect of endovascular
therapy (EVT) in mild acute ischemic stroke (AIS) due to proximal versus
distal occlusions.
Methods
We searched PubMed, Embase, the Cochrane Library, and
clinicaltrials.gov from January 2000 to September 2021 to identify
studies comparing EVT versus best medical management (BMM) in AIS with
National Institutes of Health Stroke Scale (NIHSS) scores ≤5 due to
proximal internal carotid artery (ICA) or M1 versus distal M2
occlusions. We included studies that reported the number of patients
with proximal or distal occlusions separately and reported the number of
patients with freedom of disability (modified Rankin Scale (mRS) score
0–1) or functional independence (mRS score 0–2) at 90 days in proximal
or M2 occlusions, respectively. OR with 95% CI was used.
Results
We identified six studies with 653 proximal ICA and M1 occlusion
patients and 666 distal M2 occlusion patients. Pooled results showed EVT
versus BMM was associated with a higher rate of being disability-free
in patients with proximal occlusions (OR 1.58, 95% CI 1.09 to 2.30), but
was associated with a lower rate of being disability-free in patients
with M2 occlusions (OR 0.70, 95% CI 0.49 to 0.99). Effect of EVT in
proximal versus distal occlusions was substantially different (P for
interaction=0.002). A similar pattern was seen for functional
independence (P for interaction=0.05).
Conclusions
For patients with mild AIS, observational data suggest that EVT may be
beneficial for proximal ICA or M1 but not for distal M2 occlusions.
Randomized trials are needed to confirm these findings.(Really, that's your research conclusion?)
PROSPERO registration number CRD42021281034.
Data availability statement
Data are available in a public, open access repository. Not applicable.
http://creativecommons.org/licenses/by-nc/4.0/This
is an open access article distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits
others to distribute, remix, adapt, build upon this work
non-commercially, and license their derivative works on different terms,
provided the original work is properly cited, appropriate credit is
given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Abstract
Objective
To conduct a meta-analysis to evaluate the effect of endovascular therapy (EVT) in mild acute ischemic stroke (AIS) due to proximal versus distal occlusions.
Methods
We searched PubMed, Embase, the Cochrane Library, and clinicaltrials.gov from January 2000 to September 2021 to identify studies comparing EVT versus best medical management (BMM) in AIS with National Institutes of Health Stroke Scale (NIHSS) scores ≤5 due to proximal internal carotid artery (ICA) or M1 versus distal M2 occlusions. We included studies that reported the number of patients with proximal or distal occlusions separately and reported the number of patients with freedom of disability (modified Rankin Scale (mRS) score 0–1) or functional independence (mRS score 0–2) at 90 days in proximal or M2 occlusions, respectively. OR with 95% CI was used.
Results
We identified six studies with 653 proximal ICA and M1 occlusion patients and 666 distal M2 occlusion patients. Pooled results showed EVT versus BMM was associated with a higher rate of being disability-free in patients with proximal occlusions (OR 1.58, 95% CI 1.09 to 2.30), but was associated with a lower rate of being disability-free in patients with M2 occlusions (OR 0.70, 95% CI 0.49 to 0.99). Effect of EVT in proximal versus distal occlusions was substantially different (P for interaction=0.002). A similar pattern was seen for functional independence (P for interaction=0.05).
Conclusions
For patients with mild AIS, observational data suggest that EVT may be
beneficial for proximal ICA or M1 but not for distal M2 occlusions.
Randomized trials are needed to confirm these findings.(Really, that's your research conclusion?)
PROSPERO registration number CRD42021281034.
Data availability statement
Data are available in a public, open access repository. Not applicable.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
No comments:
Post a Comment