Plasma ApoB/AI: An effective indicator for intracranial vascular positive remodeling

I'm sure there is something important in here for your recovery and prevention of your next stroke but you'll have to ask your doctor what that is. If they don't know about this research you don't have an up-to-date doctor.

Plasma ApoB/AI: An effective indicator for intracranial vascular positive remodeling

• Shi Wang
• Zhenfei Li
• Xiaotong Li
• 
  
• Cong Guo
• Xihai Zhao ¹
• Liping Chen ¹
• Show all authors
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Open AccessPublished:March 10, 2022DOI:https://doi.org/10.1016/j.jns.2022.120226

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Highlights

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  ApoB/AI is significantly higher in patients with vascular positive remodeling.
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  ApoB/AI is a better predictor for vulnerable atherosclerosis than LDL.
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  ApoB/AI reflects the balance between atherogenic and antiatherogenic particles.
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  Positive remodeling is related to plaque instability and ischemic events.

Abstract

Objectives

Both vascular positive remodeling and apolipoprotein B/apolipoprotein AI (apoB/AI) are important risk factors for ischemic stroke. However, it is unclear whether apoB/AI level plays a role in vascular positive remodeling. This study aimed to investigate the association between apoB/AI and intracranial vascular positive remodeling.

Materials and methods

Symptomatic patients with intracranial artery 30–99% stenosis were recruited and underwent high-resolution magnetic resonance (MR) imaging. The levels of apolipoprotein B (apoB), apolipoprotein AI (apoAI) and apoB/AI were tested. Intracranial vascular remodeling index (RI) defined as the wall area ratio between maximal luminal narrowing and reference site was evaluated on MR images. Positive remodeling was defined as RI ≥1.05. The association between apoB/AI level and positive remodeling was respectively determined in anterior and posterior circulation.

Results

Of 65 recruited patients (mean age: 58.5 ± 10.6 years; 36 males), 25 (38.5%) had positive remodeling, of which 24 (36.9%) were in the posterior circulation group. Patients with positive remodeling had significantly higher apoB (1.0 ± 0.3 g/L vs. 0.8 ± 0.3 g/L, P = 0.003) and apoB/AI (1.0 ± 0.3 vs. 0.8 ± 0.2, P = 0.008) than those without. Univariate logistic regression showed that apoB/AI (OR: 2.302, 95%CI: 1.229–4.321, P = 0.009) was significantly associated with positive remodeling. After adjusted for confounders, the association of apoB/AI (OR: 2.935, 95%CI: 1.061–8.123, P = 0.038) with positive remodeling remained significant. ApoB/AI (OR: 76.110, 95%CI: 1.169–4953.287, P = 0.042) was significantly associated with positive remodeling in posterior circulation but not in anterior circulation.

Conclusion

ApoB/AI is a potential indicator for intracranial vulnerable atherosclerosis characterized by positive remodeling, especially in posterior circulation.