ABSTRACT
Objective
To
determine the effects of virtual reality (VR) rehabilitation training
on the cognitive function and activities of daily living (ADLs) of
patients with post-stroke cognitive impairment (PSCI).
Data sources
Four
Chinese databases and six English databases were systematically
searched for studies published until August 31, 2021, by using MeSH
terms such as virtual reality, cognition disorders, cognitive
dysfunction, and stroke, and free terms such as virtual environment, VR,
cognition impairment, cerebrovascular accident, and PSCI.
Study Selection
Randomized
controlled trials treating PSCI with VR training were included. The
control groups received conventional treatments such as conventional
rehabilitation training and drug therapy; the experimental groups
received VR rehabilitation training. The outcome measures were cognitive
function and ADLs.
Data Extraction
Two
researchers independently extracted key information from eligible
studies. The methodological quality of the studies was evaluated using
the Cochrane Handbook for Systematic Reviews of Interventions v5.1.0. Meta-analysis was performed using RevMan v5.4. We followed the PRISMA 2020 guidelines.
Data synthesis
Twenty-one
studies (1149 participants) were included. Meta-analyses found that
compared with the control group, VR rehabilitation training increased
MMSE, MoCA, LOTCA, RBMT-II, BI, MBI, and FIM scores, P300 amplitude, and
the NAA/Cr ratio on 1H-MRS, and reduced P300 latency, TMT scores, and the Cho/Cr ratio on 1H-MRS (all P < 0.05). These results indicated that VR training improved cognitive function and ADLs in PSCI.
Conclusion
VR
rehabilitation training promotes the rehabilitation of cognitive
function and recovery of ADLs in PSCI patients, and may be a good
complementary approach to conventional cognitive interventions.
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