With your good chance of getting dementia or Parkinsons, what is your doctor's EXACT PROTOCOL to fix those gut mitochondrial defects?
Your risks of dementia, has your doctor told you of this?
2. Then this study came out and seems to have a range from 17-66%. December 2013.`
Where are the protocols to prevent your dementia?
Your risk of Parkinsons here:
The latest here:
Nature Aging
volume 2, pages 277–279 (2022)Cite this article
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Neurodegenerative
diseases, including Parkinson’s disease, are linked to the accumulation
of defective mitochondria in the brain and to microbial dysbiosis in
the gut. However, the interplay between these factors is incompletely
understood. Fedele et al. reveal how gut mitochondrial dysfunction
activates intestinal inflammation to drive neurodegeneration in a
Parkinson’s disease model.
PD is an age-related
neurodegenerative disease with symptoms ranging from mild tremors,
speech disturbances and impaired writing ability to more severe
manifestations such as slowed movements (bradykinesia), rigid muscles,
impaired posture and balance, and loss of automatic movements. Over 10
million people worldwide have PD. As mitochondria accumulate damage with
age, quality control mechanisms are essential to ensure homeostasis and
maintain healthy cells and tissues. Dysfunctional mitochondria can be
cleared and recycled via a specialized form of autophagy known as
mitophagy. The gene PINK1 regulates mitophagy through recruitment of parkin to the outer membrane of depolarized mitochondria to tag it for degradation3. Mutations in the PINK1
gene have been linked to a form of familial PD and are associated with
altered expression of metabolic and immune response genes3.
Although hereditary mutations can affect cell physiology throughout the
entire body, it seems reasonable to assume that impaired mitochondria
in brain tissue has a prominent role in PD-related neurodegeneration.
However, there are previously identified clues that suggest that
alterations in the intestine could precede neurodegeneration in PD. For
example, studies in patients with PD have shown that α-synuclein
aggregates (which can contribute to PD) accumulate in peripheral nerves,
including those that innervate the intestine4. These α-synuclein aggregates can propagate to the central nervous system, where they accumulate and cause neurotoxicity4. The primary question that the authors set out to address in this study2 was whether mitochondrial dysfunction in brain tissue alone is responsible for PD-related neurodegeneration in the Pink1 Drosophila model of PD.
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