Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature

WHOM is going to take this, update the stroke strategy and start figuring how to use this to get survivors recovered?  Will never occur, we have NO leadership and NO strategy.

I'm sure nothing will be done since nothing was done with this from January 2012

Take Two Robots and Call Me in the Morning January 2012

10 YEARS! THAT'S HOW FUCKING BAD THE STROKE MEDICAL WORLD IS! Completely dysfunctional.

Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature

Paul Wrede1,2,3 , Oleksiy Degtyaruk1,2 , Sandeep Kumar Kalva1,2 , Xosé Luis Deán-Ben1,2 , Ugur Bozuyuk3 , Amirreza Aghakhani3 , Birgul Akolpoglu3 , Metin Sitti2,3,4 *, Daniel Razansky1,2 * 

1 Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland. 2 Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, 8093 Zurich, Switzerland. 3 Physical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569 Stuttgart, Germany. 4 School of Medicine and College of Engineering, Koç University, Istanbul 34450, Turkey. *Corresponding author. Email: sitti@is.mpg.de (M.S.); daniel.razansky@uzh.ch (D.R.)

 

Mobile microrobots hold remarkable potential to revolutionize health care by enabling unprecedented active medical interventions and theranostics, such as active cargo delivery and microsurgical manipulations in hard-toreach body sites. High-resolution imaging and control of cell-sized microrobots in the in vivo vascular system remains an unsolved challenge toward their clinical use. To overcome this limitation, we propose noninvasive real-time detection and tracking of circulating microrobots using optoacoustic imaging. We devised cell-sized nickel-based spherical Janus magnetic microrobots whose near-infrared optoacoustic signature is enhanced via gold conjugation. The 5-, 10-, and 20-m-diameter microrobots are detected volumetrically both in bloodless ex vivo tissues and under real-life conditions with a strongly light-absorbing blood background. We further demonstrate real-time three-dimensional tracking and magnetic manipulation of the microrobots circulating in murine cerebral vasculature, thus paving the way toward effective and safe operation of cell-sized microrobots in challenging and clinically relevant intravascular environments.