Investigating the Neuroprotective Effects of Cannabinoids and Insulin-like Growth Factors on Glia with Induced Inflammation

 

Yeah this is for TBI, but your doctor should have enough functioning brain cells to be able to apply it to stroke.

Investigating the Neuroprotective Effects of Cannabinoids and Insulin-like Growth Factors on Glia with Induced Inflammation

William S. Dodd,1 Eric J. Panther,1 Kevin Pierre,1 Jairo S. Hernandez,1 Devan Patel,2 Brandon LuckeWold1,* 1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL 2. Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY * Correspondence to: Brandon Lucke-Wold, MD, PhhD Lillian S. Wells Department of Neurosurgery 1505 SW Archer Rd Gainesville, FL 32608 brandon.lucke-wold@neurosurgery.ufl.edu

 

Abstract Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. The complex nature of these pathologies can make clinical assessment, diagnosis, and treatment challenging. The goal of this review is to provide a concise appraisal of the literature with focus on emerging strategies to improve clinical outcomes. First, we review the pathways involved in the pathogenesis of neurotrauma-related neurodegeneration and discuss the clinical implications of this rapidly evolving field. Next, because clinical evaluation and neuroimaging are essential to the diagnosis and management of neurodegenerative diseases, we analyze the clinical investigations that are transforming these areas of research. Finally, we briefly review some of the preclinical therapies that have shown the most promise in improving outcomes after neurotrauma