Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,372 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Context High serum or dietary levels of vitamin E and beta carotene appear to be associated with lower risk of stroke, but studies regarding their supplementation have not supported their use in stroke prevention.
Objective To determine if vitamin E (dl-alpha tocopherol) and beta carotene supplementations could be used in prevention of stroke in men at high risk for hemorrhagic or ischemic events.
Design Population-based, randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial (the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study), conducted from April 1985 through April 30, 1993, with median follow-up of 6 years.
Interventions Alpha tocopherol, 50 mg; beta carotene, 20 mg; both; or placebo.
Participants From the total male population aged 50 through 69 years in southwestern Finland (n = 290,406), 29,133 male smokers were randomized to 1 of 4 treatment regimens. We excluded 614 men because of previous stroke at baseline, leaving 28,519.
Main Outcome Measures Incident and fatal subarachnoid and intracerebral hemorrhage, cerebral infarction, and unspecified stroke.
Results Stroke occurred in a total of 1057 men: 85 had subarachnoid and 112 had intracerebral hemorrhage, 807 had cerebral infarction, and 53 had unspecified stroke. Within 90 days from onset, 160 men died of stroke. Vitamin E supplementation increased the risk of subarachnoid hemorrhage (relative risk [RR], 2.45; 95% confidence interval [CI], 1.08-5.55) and decreased risk of cerebral infarction (RR, 0.70; 95% CI, 0.55-0.89) in hypertensive men but had no effect among normotensive men. Furthermore, it decreased the risk of cerebral infarction, without elevating the risk of subarachnoid hemorrhage, among hypertensive men with concurrent diabetes (RR, 0.33; 95% CI, 0.14-0.78). Beta carotene supplementation appeared to increase the risk of intracerebral hemorrhage and modestly decrease that of cerebral infarction among men with greater alcohol consumption.
Conclusion Vitamin E supplementation may prevent ischemic stroke in high-risk hypertensive patients, but further studies are needed.
VITAMIN E and beta carotene may act as antioxidants against atherosclerosis and thus prevent cerebrovascular diseases.1,2 Besides the antioxidant effects, vitamin E and its metabolites have antiplatelet and anticlotting actions,3-6 but the clinical importance of these actions is obscure. In our controlled trial on male smokers, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, vitamin E (dl-alpha tocopherol) supplementation increased the incidence and mortality due to subarachnoid hemorrhage but decreased the incidence of cerebral infarction, whereas beta carotene supplementation increased the incidence of intracerebral hemorrhage.7
Our aim was to examine whether there were subgroups that benefited from supplementation with vitamin E or beta carotene without an increased risk for bleeding. For this, we analyzed the effect modification of age, systolic blood pressure, serum total and high-density lipoprotein (HDL) cholesterol levels, histories of diabetes and heart disease, number of cigarettes smoked daily, alcohol consumption, and physical activity on the effects of vitamin E supplementation on subarachnoid hemorrhage and cerebral infarction, and that of beta carotene supplementation on intracerebral hemorrhage and cerebral infarction in the ATBC Study.
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