Wednesday, August 31, 2022

Aging, testosterone, and neuroplasticity: friend or foe?

 Ask your doctor what the full article says about using testosterone for neuroplasticity.

All this other stuff for your doctor to know about;

Well your doctor has a lot of studying to do. 

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FDA warns about blood clot risk with testosterone products


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Lower Testosterone Levels Predict Incident Stroke and Transient Ischemic Attack in Older Men

 

Could androgens maintain specific domains of mental health in aging men by preserving hippocampal neurogenesis?


Single-Dose Testosterone Administration Impairs Cognitive Reflection in Men

The latest here:

Aging, testosterone, and neuroplasticity: friend or foe?

Kiarash Saleki ORCID logo, Mohammad Banazadeh ORCID logo, Amene Saghazadeh and Nima Rezaei

Abstract

Neuroplasticity or neural plasticity implicates the adaptive potential of the brain in response to extrinsic and intrinsic stimuli. The concept has been utilized in different contexts such as injury and neurological disease. Neuroplasticity mechanisms have been classified into neuroregenerative and function-restoring processes. In the context of injury, neuroplasticity has been defined in three post-injury epochs. Testosterone plays a key yet double-edged role in the regulation of several neuroplasticity alterations. Research has shown that testosterone levels are affected by numerous factors such as age, stress, surgical procedures on gonads, and pharmacological treatments. There is an ongoing debate for testosterone replacement therapy (TRT) in aging men; however, TRT is more useful in young individuals with testosterone deficit and more specific subgroups with cognitive dysfunction. Therefore, it is important to pay early attention to testosterone profile and precisely uncover its harms and benefits. In the present review, we discuss the influence of environmental factors, aging, and gender on testosterone-associated alterations in neuroplasticity, as well as the two-sided actions of testosterone in the nervous system. Finally, we provide practical insights for further study of pharmacological treatments for hormonal disorders focusing on restoring neuroplasticity.


Corresponding author: Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, 14197 33151 Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, 14176 13151 Tehran, Iran; and Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), 14197 33151 Tehran, Iran, E-mail:
Kiarash Saleki and Mohammad Banazadeh contributed equally to this work.

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